MG132 (MG-132) _ 52801ES INF Published 2021 Mar 17

Published 2021 Mar 17

ELISA Data: Immobilized Human PLAU

while the target genes are all greater than 30

S291277(IF:3

Before gel filling

MG132 (MG-132) _ 52801ES INF Published 2021 Mar 17MG132 is a potent, reversible, cell permeable proteasome inhibitor (IC50=100 nM), more than 1000 fold more potent than ZLLal in inhibiting the ZLLL MCA degradation activity of the 20S proteasome. MG132 also inhibits the cell cycle and calpain required for cyclin degradation (IC50=1. 2 M), and induces neurite outgrowth in PC12 cells. In addition, MG132 inhibited IB degradation, thereby inhibiting NF B pathway activation. MG132 induces apoptosis of MPM