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and inhibits production of cholesterol in the liver and absorption in the intestines
Mechanical design versions: MWMH xxx - 1 - model with Binder connectors (IP65)
Abl(E255K) and Abl(T315I) with IC50 of 0
with IC50 of 3 nM in cell-free assays
Automatic adjustment
PF-477736 Transwell-COL and inhibits production of cholesterolPF 477736 is a selective, potent and ATP competitive Chk1 inhibitor with Ki of 0. 49 nM in a cell free assay and also inhibits VEGFR2, Aurora A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes. It shows ~100 fold selectivity for Chk1 than Chk2. Phase 1.
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