HaXS8 Size:100nmol 078 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCOCCOCCOCCO)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)

078 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCOCCOCCOCCO)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

and oligonucleotides

1038/s41586-019-1722-1

Product Name Azide-Lys(m-PEG4)-Val-Ala-PAB(m-PEG4)-MMAE Synonyms CAS Number Related CAS Molecular Formula C81H135N13O22 Molecular Weight 1643

S)-AHPC-CO-C6-NH2 HCl Synonyms CAS Number 2360522-76-3 Related CAS 2306389-03-5 (free base)

HaXS8 Size:100nmol 078 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCOCCOCCOCCO)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)HaXS8 is a synthetic chemical dimerizer designed to induce covalent and irreversible intracellular dimerization between proteins tagged with HaloTag and SNAP tag. Its a bifunctional molecule featuring a chloroalkane group (specific for HaloTag) and an O6 benzylguanine (BG) derivative (specific for SNAP tag), connected by a flexible polyethylene glycol (PEG) linker. When introduced to cells, HaXS8 bridges HaloTag and SNAP tag fusion proteins by