With the MTG Spider-Man set drawing near, theres going to be a ton of players looking towards building Spider decks
There are also commanders that exploit life loss, with Ob Nixilis, Captive Kingpin, Valgavoth, Harrower of Souls, and Rakdos, Lord of Riots (its a very Rakdos-coded mechanic)
We can extrapolate this to say that in general, if smaller creatures are major threats, then more expensive removal is worse and that if smaller creatures are minor threats, then more expensive removal is better
If you can combine it with Ephemerate, as the four-colour decks often do, you can set up some devastating turns where you just wipe the opponents board
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Fun Ranking: Kinda Fun Kykar, Zephyr Awakener I like this new take on Kykar