The combo is highly modular and easy to set up so she's a strong contender for a more competitive version of the deck, however this would take the deck into a focused Combo direction, which a (very vocal) part of my viewers would loudly complain about if I took the deck this direction, so let's not
The cards are too expensive for Wizards to put them in a Commander precon, but they'll likely want to increase supply before Lost Caverns of Ixalan releases, which makes Commander Masters a pretty obviously landing spot
At a base, it'll be a 1/1 with trample, but with each creature being put on the battlefield, that'll only go up
Niv-Mizzet, Visionary Niv-Mizzet is back and just as terrifying when he hits the table as ever
In other words, if you want to cast a Stonecoil Serpent while controlling Etherium Sculptor, you can cast it for X=1 without paying any mana, X=2 by paying a single mana, etc
The times it costs two will not often be a big deal but the times it cost nothing are huge